Integrative Medicine
and Functional Medicine for Chronic
Hypertension: An Evidence-based
Monograph on the Treatment of High Blood Pressure
"Your writing is very good, clear, concise and accurate."
World-renowned cardiologist and expert researcher in CoQ-10, 2011
"Once again, an outstanding resource for
clinicians. Your contributions to the field are remarkable!"
Clinician, University President, Journal Editor, 2011
"I appreciate the resources you offer the profession. I use your
books and articles regularly." Chiropractic Doctor, 2011
"Thank you for exposing so many people to the results of our
research on the treatment of hypertension. I hope you can pay us a
visit during your next trip to our area so we can give you the tour
of our new 50+ bed inpatient facility."
Alan Goldhamer, D.C.,
Chief of Health Promoting Clinic, 2010
"Dr. Vasquez artfully contends that chronic hypertension is a
clinical finding of vascular dysfunction that is best managed with
exercise and dietary measures, and that chiropractic doctors are
uniquely positioned to provide such management. I wholeheartedly
agree with him." Joseph Brimhall, D.C. President,
University of Western States, 2010
"I attended your seminar at Western States University in June
and have been utilizing your hypertension protocols. In that short
time, I have seen some marked progress with various patients. I was
wondering if you have or in the process of developing a new patient
brochure that briefly explains the chiropractic, nutritional and
exercise approach to hypertension. I think a folded brochure to add
to my existing patient education brochures would be helpful and
prompt potential patients to consult our offices."
Chiropractic
Doctor, 2010
"As a 7th trimester student quickly approaching
8th trimester and student clinic, I know I will be utilizing your
books often. Your "Chiropractic and Naturopathic Mastery of Common
Clinical Disorders" book is referenced very frequently by many
clinicians and faculty members at [our university]. Your work is
highly regarded, and I look forward to clinically utilizing the
information I will obtain from your writings."
Chiropractic-Naturopathic Student, 2011
Integrative Medicine and Functional Medicine for Chronic
Hypertension provides healthcare professionals,
policymakers, and the educated public more than a review of
treatments for chronic hypertension; this book outlines and
substantiates a paradigm shift that will broaden the reader’s
perspective and enable a new approach to hypertension management
and disease prevention. Further, in the process of exploring the
topic of hypertension, readers will see how the functional
medicine approach that is described herein can be applied to
other important health problems commonly encountered in clinical
practice and public health.
Hypertension—commonly known as high
blood pressure—is the most common diagnosis in the practice of
medicine, and it affects an estimated one billion people
worldwide and at least 50 million people in the United States.
The global prevalence is approximately 25%, meaning that 1 of
every 4 persons in the world has high blood pressure. Because
the underlying metabolic problems (dysfunctions) that cause
hypertension are becoming more common, by the year 2025 the
number of affected persons is estimated to reach 1.56 billion
people worldwide. Clearly, everyone with a stake in healthcare
and with concern about their own personal health—from
physicians, to politicians, to the general public—can benefit
from the approaches described in this book that promote optimal
health and the prevention of diseases in general, hypertension
in particular.
This textbook teaches the public and the healthcare communities
how to (re)create the social and personal environments to
promote optimal health—wellness—and then details the causes,
respective assessments, lab tests, and the best treatment
approaches for chronic hypertension. Patients with the condition
and the doctors who care for them will all benefit from the
information in this book, which is supported by hundreds of
scientific publications, years of clinical experience, and Dr
Vasquez’s unique perspective from his diverse training
encompassing three doctoral degrees in three separate healthcare
professions.
About the author: Dr.
Alex Vasquez is a graduate of Western States Chiropractic
College (Doctor of Chiropractic, 1996), Bastyr University
(Doctor of Naturopathic Medicine, 1999), and University of North
Texas Health Science Center, Texas College of Osteopathic
Medicine (Doctor of Osteopathic Medicine, 2010). Dr Vasquez is
the author of several textbooks—Integrative Orthopedics (2004,
2007) Integrative Rheumatology (2006, 2007), Musculoskeletal
Pain: Expanded Clinical Strategies (published by the Institute
for Functional Medicine, 2008), Chiropractic and Naturopathic
Mastery of Common Clinical Disorders (2009), Chiropractic
Management of Chronic Hypertension (2010)—and more than 75
letters and articles in professional magazines and medical
journals such as The Lancet, BMJ—British Medical Journal, Annals
of Pharmacotherapy, Nutritional Perspectives, JMPT—Journal of
Manipulative and Physiological Therapeutics, JAMA—Journal of the
American Medical Association, Original Internist, Integrative
Medicine, Holistic Primary Care, Alternative Therapies in Health
and Medicine, JAOA—Journal of the American Osteopathic
Association, Dynamic Chiropractic, Journal of Clinical
Endocrinology and Metabolism, and Arthritis &
Rheumatism—Official Journal of the American College of
Rheumatology.
Integrative Medicine
and
Functional Medicine
for
Chronic Hypertension:
An
Evidence-based Monograph on the Treatment of High Blood Pressure
Dietary,
Nutritional, Botanical, Surgical, and Manipulative Therapeutics
with
Concepts, Perspectives, Algorithms, and Protocols for
the Safe
and Effective Management of Chronic High Blood Pressure
Dr. Alex Vasquez
Doctor of Osteopathic Medicine,
graduate of University of North Texas Health Science Center, Texas
College of Osteopathic Medicine (May 2010). Currently in training for
Family Medicine
Doctor of Naturopathic Medicine,
graduate of Bastyr University (September 1999). Licensed Naturopathic
Physician with Additional Prescriptive Authority in Washington
(2000-2002), Licensed Naturopathic Physician in Oregon (2004-present)
Doctor of Chiropractic,
graduate of Western States Chiropractic College (March 1996. Licensed
Doctor of Chiropractic, Washington (1996-2002) and Texas (2002-present)
Adjunct Faculty (2004-2005, 2010) and Former Forum Consultant
(2003-2007), The Institute for Functional Medicine in Gig Harbor,
Washington
Adjunct Faculty, National University of Health Sciences in Lombard,
Illinois
Affiliate Faculty, University of Western States in Portland, Oregon
Private practice of chiropractic and naturopathic medicine in Seattle,
Washington (2000-2001) and Houston, Texas (2001-2006)
Former Adjunct Professor of Orthopedics (2000), Radiographic
Interpretation (2000), and Rheumatology (2001) at Bastyr University in
Kenmore, Washington
Former Editor (2006-2007),
Naturopathy Digest
Author of approximately 75 articles and letters published in
Annals
of Pharmacotherapy, The Lancet, Nutritional Perspectives, BMJ (British
Medical Journal), Journal of Manipulative and Physiological
Therapeutics, JAMA (Journal of the American Medical Association), The
Original Internist, Integrative Medicine: A Clinician's Journal,
Holistic Primary Care, Nutritional Wellness, Dynamic Chiropractic,
Alternative Therapies in Health and Medicine, Journal of the American
Osteopathic Association, Evidence-based Complementary and Alternative
Medicine, Journal of Clinical Endocrinology and Metabolism, and Arthritis & Rheumatism: Official Journal of the American College of
Rheumatology
Dr. Alex Vasquez comes to the question of the origins of
hypertension with a perspective and set of tools that presage
21st century functional systems medicine. We currently have in
place in the industrialized world a method of healthcare
developed and based on the 20th century acute-care medical
model. Such a model is characterized by rapid differential
diagnosis—with an organ-system focus—aimed at prescribing a drug
(or procedure) that will ameliorate the patient’s presenting
symptoms and signs, averting the immediate threat.[1] It is a
model that evolved in response to the primary causes of
morbidity and mortality in the last century, namely acute
infections and trauma. The experts within this organ-system
model are the various specialists within conventional medicine,
such as cardiologists, pulmonologists, endocrinologists,
neurologists, and orthopaedic surgeons.
Inherently, this methodology minimises the involvement of the
patient, who functions mostly as a passive recipient of the
procedure or prescription. It is not a model that reimburses the
practitioner for looking into why the patient became ill, the
origins of illnesses. Instead, it prioritises immediate
solutions to the most pressing problems. It is, of course,
absolutely essential in emergency and hospital-based care of
many kinds, but difficulties arise when this model is applied to
ongoing, community-based care for the non-acute, chronic,
complex conditions that represent 80% of the daily work of
present day clinicians.[2]
This new book,
Integrative Medicine and Functional Medicine for Chronic
Hypertension, discusses the principles of functional integrative
medicine and shows how they can be usefully applied to the
frequently encountered clinical condition of chronic
hypertension. In so doing, it illustrates the shift that will be
required to enfold into 21st century medical practice the
innovative clinical practises of patient-centred, personalised,
systems-based medicine. A core principle of functional
integrative medicine maintains that diagnosis is the starting
point for the clinician’s primary set of responsibilities, not
the last step before prescriptive interventions. The most
complex of skills, clinical decision making and medical
judgment, in the medical context of chronic, complex co-morbid
illnesses such as chronic hypertension, require:
• A persistent exploration of the accretion of the relevant
scientific evidence, tempered by…
• the wealth of knowledge and judgment inherent in clinical
experience, along with…
• the creation of a real partnership with the patient in educing
a lifestyle-based personalized, therapeutic plan.
Clinical decision making, when exercised at the most efficacious
level, drills deeply into the “why” of every diagnosis. Pursuit
of the elusive network of causality in the deeper intersections
of genetic individuality, within each client’s unique context of
living, is an essential responsibility of the clinician. This
clinical guide focused on chronic hypertension illustrates,
using step-by-step illustration, how to achieve more satisfying
outcomes through an integrated clinical assessment and treatment
program.
Stepping out of the shadow of conventional poly-pharmacology and
procedure-based interventions, into the bright sunlight afforded
by 21st century breakthroughs in personalised medicine, systems
biology, and systems medicine re-enchants and illuminates the
practice of clinical medicine. The blending of the foundational
sciences of genomics (unique genes embedded in a unique
environment) with the intellectual architecture of functional,
integrative, systems-thinking enables the creation of a more
comprehensive portfolio of clinical service for the patient. The
author’s careful explanations in this volume illustrate how
clinical practice, coupled with skills learned through rigorous
training in both conventional medicine and functional,
integrative systems medicine can successfully bring to the
therapeutic relationship real patient-centred answers for
chronic, complex illnesses.
The most powerful motivator for changes in our behavior as
physicians is listening attentively to compelling stories
brought to the clinic by our patients. The intense satisfaction
of successfully resolving their hitherto unanswered questions
about the root causes of chronic hypertension, by applying a
different lens for evaluation and assessment, is transformative.
Functional, integrative, systems medicine provides such a lens.
Hence,
Integrative Medicine and Functional Medicine for Chronic
Hypertension
will prove to be an important publication about functional and
integrative medicine in clinical practice.
David S Jones, MD
President, Institute for Functional Medicine
August, 2010
[1] Ely JW, Osheroff JA, Gorman PN, et al. A
taxonomy of generic clinical questions: classification study.
BMJ 2000;321:429-32
[2] Holman H. Chronic disease—The need for a new clinical
education. JAMA 2004;292(9):1057-1059
In his newly updated
publication, Dr. Vasquez’s expanded volume encourages and
challenges clinicians to further re-imagine their roles in the
delivery of health care services. His particular focus on the
care of patients with chronic hypertension emphasizes that high
blood pressure is both an indicator of underlying functional
disorders and a contributor to other serious health problems.
As Dr. Vasquez notes, heart
disease and vascular disorders cause tremendous losses in
quality of life for a large segment of the population and are
the primary causes of death in our society. Chronic high blood
pressure is both a cause of and an indicatorof
vascular dysfunction and disease. For the most part, these
health problems are self-inflicted, meaning that they are the
result of how we live, what we eat, and how we view health (and
healthcare) in general. Consequently, Dr. Vasquez submits that
patients with vascular problems as indicated by chronic
hypertension are best managed through dietary changes,
nutritional interventions, exercise and other lifestyle
modifications. These natural approaches are almost always more
safe and effective than conventional drug-based therapies.
Throughout his series of
patient-management reference texts for functional integrative
clinicians, Dr. Vasquez promotes a simple yet profound
principle; “The art of co-creating wellness while effectively
managing common health disorders.”Chiropractic
physicians, as with other functional integrative clinicians, are
uniquely positioned to implement this advice. The methods he
recommends are specifically designed to optimize function and
facilitate health. As healthcare professionals, we can provide
no higher service than that of addressing the needs of those
patients who seek our care by treating them as individuals,
and by seeing them as whole people and not just as hosts
of disease.
Clinical evaluation and
management of patients with chronic hypertension should and can
be done by all functional integrative clinicians, and Dr.
Vasquez’s text shows how this can be accomplished. The benefits
of this protocol extend beyond reduced hypertensive morbidity
and mortality to include the alleviation of comorbid conditions
such as depression, migraines, and back pain and the enhancement
of vitality and sense of well-being.
Dramatic change in health care
delivery is in the air; it is the clinician’s responsibility to
ensure that the conversation centers on the care of the
patient. In placing as first priority the needs and
preferences of the patient,functional integrative
cliniciansdemonstrate capacity to improve health care
choices for individuals while also positively impacting the
entire healthcare delivery system by reorienting it toward
health optimization rather than symptom suppression
and disease treatment.
The quest for a better way to
achieve and maintain a healthy life compels us to adapt, to
modify, and to transform. Such is the path of advancement and
growth. I commend Dr. Vasquez’s excellent work and encourage
functional integrative clinicians to embrace and apply his
recommendations.
The chiropractic profession now has a
clinically oriented handbook thoroughly referenced to peer-reviewed
publications detailing the evaluation and management of chronic
hypertension. Up until now, the profession in general and
practitioners as individuals had no specific outline for the
integrative chiropractic management of high blood pressure, and thus
the profession’s claim to “primary care” in this respect carried
little authoritative weight. With this new clinical handbook,
clinicians can confidently navigate the steps that constitute the
clinical evaluation, differential diagnosis, physical/laboratory
examination, and then implement (as appropriate) the nutritional and
manipulative treatments that are essential components of successful
hypertension management. [1]
After several years of integrative chiropractic
and naturopathic practice, I decided to attend medical school for my
third doctoral degree. Many reasons inspired me to take on this
challenge; but one of the major ones has been that of continually
challenging my own perspectives, opinions, and paradigms with regard
to the clinical management of various diseases, disorders, and
conditions. Four years later and after scoring in the top 1-5% on
national medical exams and performing very well at one of the
nation’s top medical schools, my perspective on the appropriate
management of chronic hypertension remains steadfast in three of its
primary components: 1) Nutritional, lifestyle, and manipulative
interventions should be the treatments of choice for essentially all
patients with chronic primary hypertension. 2) As the only
nationally licensed healthcare discipline with training in
nutritional, lifestyle, and manipulative interventions, the
chiropractic profession should play a premier national role in the
management of chronic hypertension. 3) Pharmacosurgial
interventions are important for medical causes and recalcitrant
cases of hypertension. Since premises #2 and #3 founded upon or
associated with premise #1, I will provide some substantiation here
for premise #1; details and citations are provided in the textbook.
As a diagnosis and clinical disorder affecting
approximately 25% of American adults, hypertension is the single
most common diagnosis made in the general practice of Family
Medicine. In this article as in my recent textbook, the term
“chronic hypertension” refers to the 90% of all hypertension cases
labeled as “primary” or “essential” or “idiopathic” hypertension,
i.e., those that lack any routine “medical” cause, such as
hypercalcemia, hyperaldosteronism, aortic coarctation, renovascular
disease, renal parenchymal disease, systemic sclerosis, drug
iatrogenesis, hyperthyroidism or hypothyroidism. Chronic
hypertension accelerates the development of atherosclerosis and is
thus a major risk factor for stroke and myocardial infarction.
Additionally, the physiologic consequences of sustained high blood
pressure contribute to the development of congestive heart failure,
hypertensive retinopathy, and hypertensive kidney disease. Of
course, combining chronic hypertension with other risk factors such
as smoking, diabetes mellitus, and dyslipidemia causes an
exponential increase in the risk for catastrophic cardiovascular
morbidity and mortality. Because treatment of hypertension is the
single most effective means for reducing premature morbidity and
mortality in developed nations, the management of hypertension ranks
highly among the most important public health issues in America,
Canada, Australia, Japan, England and most of Western Europe while
still being important in South America, the Middle East, and the
rest of Asia. In other words, chronic hypertension is a worldwide
health disorder of the highest clinical and public health
importance.
The safest, most effective, and most
appropriate treatments for the vast majority of cases of chronic
hypertension are within the chiropractic scope of practice; these
treatments are nutritional intervention and manipulative therapy.
As reviewed in Chiropractic Management of Chronic
Hypertension, many dietary and nutritional interventions
are impressively well-documented in the research literature; because
these interventions are also preferred by patients and are
preferentially utilized clinically by many doctors, all three
criteria for evidence-based medicine are satisfied (i.e., research
substantiation, clinicians’ utilization, and patient preference).
Most chiropractors are probably unaware that the most effective
nutritional treatment for chronic hypertension has been researched
and documented by Dr Alan Goldhamer, a chiropractic doctor and
graduate of Western States Chiropractic College (now University of
Western States). Writing in the June 2001 issue of
Journal of Manipulative and Physiological
Therapeutics, Dr Goldhamer and his colleagues showed
that the combination of diet improvement along with fasting
normalized blood pressure in nearly 90% of 174 consecutive patients
with hypertension. The average blood pressure reduction was -37/-13
mm Hg with the use of diet and fasting; in contrast, when
hypertension is managed with drugs, achieving a reduction in blood
pressure of -20/-10 generally requires at least two medications.
Patients with systolic blood pressure greater than 180 mg Hg or
diastolic blood pressure greater than 110 mg Hg (or both) had an
average reduction of 60/17 mm Hg by the end of the treatment period;
again, these results are highly significant, both statistically and
clinically. In October and December 2002 in Journal of
Alternative and Complementary Medicine, Dr Goldhamer again
showed that drug-free dietary intervention was highly effective and
that it saved employers-insurers thousands of dollars per patient,
with additional savings expected to result from improved overall
health and the continued implementation of health-promoting dietary
and lifestyle changes. Dr Goldhamer’s diet and fasting intervention
was performed on an inpatient basis; with appropriate patient
selection, variations on supplemented fasting can be performed on an
outpatient basis with once or twice weekly clinical evaluation.
The five-part “supplemented Paleo-Mediterranean diet” which I first
detailed in September 2005 issue of Nutritional Wellness
[2] can also be used to promote and maintain long-term reductions in
blood pressure and to enhance overall health.
In addition to specific diet
modifications, certain nutritional supplements should be used in the
routine treatment of chronic hypertension. Nutritional supplements
with evidence-based substantiation in the research literature
include but are not limited to coenzyme Q-10, vitamin D, magnesium,
vitamin C, L-carnitine and acetyl-L-carnitine. Beyond the direct
and collateral benefits provided by dietary and nutritional
supplementation are the synergistic benefits obtained when dietary
improvement is combined with nutritional supplementation (rather
than diet alone or supplementation alone). Chiropractic doctors
need to know how to use these nutritional interventions safely and
effectively. Important clinical characteristics of a given
treatment include: 1) expected blood pressure reduction from each
treatment, 2) collateral benefits, 3) drug interactions, 4) risks of
therapy, 5) identification of responsive or resistant patient
groups, and 6) how to implement nutritional interventions in
patients taking pharmaceutical drugs.
Documentation of the
effectiveness of chiropractic spinal manipulation in the treatment
of chronic hypertension was most recently published in the May 2007
issue of Journal of Human Hypertension by Bakris and
colleagues. In this randomized trial with 50 hypertensive patients,
blood pressure reductions were -17/-10 in the treatment group
receiving upper cervical chiropractic spinal manipulation versus
-3/-2 in the placebo group. The importance of this research is at
least three-fold. First, obviously this research shows that elevated
blood pressure can be normalized without drugs; not all health
professionals respect this fact. Second, it shows specifically that
upper cervical chiropractic treatment can lower blood pressure to a
clinically meaningful degree in patients with chronic hypertension.
Third and perhaps most important, by showing that cervical spine
manipulation can reverse hypertension, this research delivers a
paradigm shift in the understanding of the pathophysiology of
hypertension. Up until recent years, the most of the
pathophysiology of chronic hypertension was ascribed to “idiopathic”
neurohormonally-mediated changes in renal handling of salt and
water; this formed the basis for the medical treatment of chronic
hypertension, which was and is largely focused on the use of
diuretics to increase excretion of salt and water. By showing that
upper cervical manipulation substantially alleviates chronic
hypertension, we have a new paradigm for expanding our concept of
the phenomenon of chronic hypertension, namely that chronic
hypertension appears to be mediated in part by neurovascular
compression at the brainstem. Although successful treatment of this
apparently common neurovascular or “neurogenic” hypertension can be
accomplished surgically (see Janetta et al in Annals of
Surgery March 1985 and Geiger et al in The Lancet
August 8, 1998), I am sure that most clinicians would appreciate the
value and safety of a nonsurgical (manipulative) approach,
especially one that can be delivered within an integrative clinical
context of dietary improvement, nutritional supplementation and
wellness coaching. By virtue of being the only nationally licensed
healthcare profession with training in spinal
manipulation/adjusting, diet therapy, nutritional supplementation,
and wellness coaching, only the chiropractic profession is poised to
deliver a packaged solution to the public health catastrophe known
as chronic hypertension. The additive and synergistic benefits of
such an approach hold enormous promise to improve the health of
patients in America, and worldwide.
Given that about 1 in 4 (25%
of total) adult Americans has hypertension, and that the
chiropractic profession is poised to deliver evidence-based
comprehensive care for these patients, 65 million hypertensive
American patients and potential patients stand to benefit from
integrative chiropractic care. The question that now remains is,
“Will the chiropractic profession stand and deliver the
science-based integrative care these patients need?” The profession
now has a guidebook for the achievement of this important goal.
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